F58B6.3 | SMap | S_parent | Sequence | F58B6
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| Chromosome | III |
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Identity (5)
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Gene_info
| Gene_class | par
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Allele (5)
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Phenotype
| it46ts mat : homozygous hermaphrodites produce 90% (16x) to 99% (25x) arrested embryos escapers sterile; abnormal early cleavages defective P granule localization. ES3 (progeny). NA4 (it5ts : weaker phenotype e2030 : grandchildless). |
| | | See also e2030 |
| | | [C.elegansII] it46ts,mat : homozygous hermaphrodites produce 90% (16C) to 99% (25C) arrested embryos, escapers sterile; abnormal early cleavages, both spindles transverse at 2nd cleavage (failure of P1 rotation), defective P granule localization. ES3 (progeny). OA7: it5ts (weaker phenotype), e2030 (Mes, grandchildless),it87 (weak),jb2, etc. All ts; temp shift indicates not needed after 2nd cleavage. Cloned: encodes predicted novel protein. Antibody staining indicates specific asymmetric cortical localizations in early blastomeres. [Cheng et al. 1995; KK] |
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Strain (5)
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GO_term
| GO:0045167
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IMP
| Paper_evidence | WBPaper00001974
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| | | | | Curator_confirmed | WBPerson324
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| | | GO:0008356
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IMP
| Paper_evidence | WBPaper00001974
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| | | | | Curator_confirmed | WBPerson324
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| | | GO:0000132
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IMP
| Paper_evidence | WBPaper00002111
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| | | | | Curator_confirmed | WBPerson324
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| | | GO:0005938
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IDA
| Paper_evidence | WBPaper00002581
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| | | | | Curator_confirmed | WBPerson324
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GO:0008270
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ISS
| Paper_evidence | WBPaper00001974
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| | | | | Curator_confirmed | WBPerson324
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| | | | IEA
| Inferred_automatically |
| | | GO:0005524
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ISS
| Paper_evidence | WBPaper00001974
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| | | | | Curator_confirmed | WBPerson324
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| | | GO:0004842
| IEA
| Inferred_automatically |
| | | GO:0016567
| IEA
| Inferred_automatically |
| | | GO:0000151
| IEA
| Inferred_automatically |
| | Contained_in_operon | CEOP3056
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Structured_description
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Provisional_description
| par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3. |
Paper_evidence (6)
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| | | | | Person_evidence | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | PAR-2 is also required for cortical contractions and cytoplasmic flow in the fertilized embryo, the asymmetric division of the zygote, known as P0, and the intrinsically programmed nuclear rotation of P lineage cells. |
| | | | PAR-2 is thought to maintain A-P polarity in part by restricting the PAR-3/PAR-6/PKC-3 complex from the embryonic posterior after pronuclear meeting. |
| | | | PAR-2 is also required for cortical and asymmetric localization of PAR-1 and enrichment of LET-99 in a cortical band in P lineage cells. |
| | | | In addition to PAR-3, PAR-6, and PKC-3, PAR-2 localization is also dependent upon PAR-5 and NYM-2. |
| | | | PAR-2 protein is excluded from the apical surface of embryonic cells by PAR-3 protein. |
| | | Concise_description | par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3. |
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Molecular_info
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Corresponding_CDS
| F58B6.3a
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| | | F58B6.3b
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Corresponding_protein
| WP:CE25917
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| | | WP:CE31016
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Corresponding_PCR_product
| smd_F58B6.3
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| | | smd_F58B6.3:2
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| | | sjj_F58B6.3
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Corresponding_RNAi_reagent (5)
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Experimental_info (5)
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Reference (178)
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| Method | Gene
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