Gene: F58B6.3
F58B6.3 | SMap | S_parent | Sequence | F58B6 | ||
---|---|---|---|---|---|---|
Chromosome | III | |||||
Identity (5) | ||||||
Gene_info | Gene_class | par | ||||
Allele (5) | ||||||
Phenotype | it46ts mat : homozygous hermaphrodites produce 90% (16x) to 99% (25x) arrested embryos escapers sterile; abnormal early cleavages defective P granule localization. ES3 (progeny). NA4 (it5ts : weaker phenotype e2030 : grandchildless). | |||||
See also e2030 | ||||||
[C.elegansII] it46ts,mat : homozygous hermaphrodites produce 90% (16C) to 99% (25C) arrested embryos, escapers sterile; abnormal early cleavages, both spindles transverse at 2nd cleavage (failure of P1 rotation), defective P granule localization. ES3 (progeny). OA7: it5ts (weaker phenotype), e2030 (Mes, grandchildless),it87 (weak),jb2, etc. All ts; temp shift indicates not needed after 2nd cleavage. Cloned: encodes predicted novel protein. Antibody staining indicates specific asymmetric cortical localizations in early blastomeres. [Cheng et al. 1995; KK] | ||||||
Strain (5) | ||||||
GO_term | GO:0045167 | IMP | Paper_evidence | WBPaper00001974 | ||
Curator_confirmed | WBPerson324 | |||||
GO:0008356 | IMP | Paper_evidence | WBPaper00001974 | |||
Curator_confirmed | WBPerson324 | |||||
GO:0000132 | IMP | Paper_evidence | WBPaper00002111 | |||
Curator_confirmed | WBPerson324 | |||||
GO:0005938 | IDA | Paper_evidence | WBPaper00002581 | |||
Curator_confirmed | WBPerson324 | |||||
GO:0008270 | ISS | Paper_evidence | WBPaper00001974 | |||
Curator_confirmed | WBPerson324 | |||||
IEA | Inferred_automatically | |||||
GO:0005524 | ISS | Paper_evidence | WBPaper00001974 | |||
Curator_confirmed | WBPerson324 | |||||
GO:0004842 | IEA | Inferred_automatically | ||||
GO:0016567 | IEA | Inferred_automatically | ||||
GO:0000151 | IEA | Inferred_automatically | ||||
Contained_in_operon | CEOP3056 | |||||
Structured_description | Provisional_description (6) | |||||
Concise_description | par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3. | |||||
Molecular_info (4) | ||||||
Experimental_info (5) | ||||||
Reference (178) | ||||||
Method | Gene |