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Gene: F58B6.3   

F58B6.3SMapS_parentSequenceF58B6
ChromosomeIII
Identity (5)
Gene_info Gene_classpar
Allele (5)
Phenotype (3)
Strain (5)
GO_term (9)
Contained_in_operonCEOP3056
Structured_description Provisional_description par-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3. Paper_evidence (6)
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
PAR-2 is also required for cortical contractions and cytoplasmic flow in the fertilized embryo, the asymmetric division of the zygote, known as P0, and the intrinsically programmed nuclear rotation of P lineage cells.
PAR-2 is thought to maintain A-P polarity in part by restricting the PAR-3/PAR-6/PKC-3 complex from the embryonic posterior after pronuclear meeting.
PAR-2 is also required for cortical and asymmetric localization of PAR-1 and enrichment of LET-99 in a cortical band in P lineage cells.
In addition to PAR-3, PAR-6, and PKC-3, PAR-2 localization is also dependent upon PAR-5 and NYM-2.
PAR-2 protein is excluded from the apical surface of embryonic cells by PAR-3 protein.
Concise_descriptionpar-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3.
Molecular_info Corresponding_CDS F58B6.3a
F58B6.3b
Corresponding_protein WP:CE25917
WP:CE31016
Corresponding_PCR_product smd_F58B6.3
smd_F58B6.3:2
sjj_F58B6.3
Corresponding_RNAi_reagent (5)
Experimental_info (5)
Reference (178)
MethodGene