RNAiDB Tree View

Gene: F58H12.1

F58H12.1	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	F58H12
	Chromosome	X
	Identity (5)
	Gene_info	Gene_class	kin
		Allele (5)
		Strain	PY1479
			VC539
			VC589
		GO_term (11)
		Structured_description	Provisional_description	kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the daur pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock and starvation, KIN-29-GFP translocates to the nucleus.	Paper_evidence	WBPaper00005098
						WBPaper00005858
						WBPaper00010223
						WBPaper00019247
					Person_evidence	WBPerson324
					Curator_confirmed	WBPerson324
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the daur pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock and starvation, KIN-29-GFP translocates to the nucleus.
	Molecular_info	Corresponding_CDS	F58H12.1
		Corresponding_protein	WP:CE28479
		KOG	KOG0583
		Corresponding_PCR_product	smd_F58H12.1
			sjj_F58H12.1
		Corresponding_RNAi_reagent	Cenix:105-c3
			sjj_F58H12.1
			yk318g5
	Experimental_info	RNAi_result	Cenix:105-c3
			JA:F58H12.1
		WB_RNAi_result	SA:yk318g5
			JA:F58H12.1
			Cenix:105-c3
		Expr_pattern	Expr1773
		Interaction (8)
	Reference (8)
	Remark	This gene (kin-29) was formerly known as sma-11 which in turn was formerly known as sns-8. [krb 030739]
	Method	Gene