F59B2.6 |
Evidence
| Paper_evidence | WBPaper00006004
|
| | CGC_data_submission |
| SMap | S_parent | Sequence | F59B2
|
| Chromosome | III |
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Identity (5)
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Gene_info
| Gene_class | zif
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| |
Allele
| gk117
| Inferred_automatically | From strain object: VC141 |
| | | tm2018
|
| | | uCE3-1089
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| | Strain | VC141
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| |
Structured_description
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Provisional_description
| zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs. |
Paper_evidence
| WBPaper00006004
|
| | | | | | WBPaper00013191
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | In yeast two-hybrid assays, ZIF-1 interacted with the zinc finger domains of PIE-1, POS-1, MEX-1 and MEX-5, but not TIS-11, by a mechanism that appears to recognize specific CCCH fingers in the degraded proteins. |
| | | | zif-1(RNAi) embryos abnormally maintain PIE-1, POS-1, MEX-1, MEX-5, MEX-6, and GFP::PIE-1(ZF1) and GFP::MEX-5(ZF2) fusions in somatic blastomeres; however, zif-1(RNAi) embryos show no effect on germline proteins that lack CCCH fingers (PAR-2 and PGL-1), on asymmetric distribution of CCCH finger proteins to germline blastomeres, or on the degradation of OMA-1 (a CCCH finger protein) in all cells after the one-cell stage. |
| | | | zif-1(RNAi) animals die during embryogenesis. |
| | | Concise_description | zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs. |
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Molecular_info (5)
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Experimental_info
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RNAi_result
| Cenix:308-b1
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| | | JA:F59B2.6
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| | | TH:308B1
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WB_RNAi_result (5)
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Reference (7)
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Remark
| Gene name created from parsing 'genotype' field from CGC strain information [krb 020721] |
| | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene
|