GO_term: GO:0005967   

GO:0005967	Definition	Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
		Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).
	Term	pyruvate dehydrogenase complex (sensu Eukarya)
		pyruvate dehydrogenase complex (sensu Eukaryota)
	Type	Cellular_component
	Parent	Instance_of	GO:0045254
		Component_of	GO:0005759
	Attributes_of	Index	Ancestor	GO:0000274
				GO:0000276
				GO:0000500
				GO:0000924
				GO:0000925
				GO:0000927
				GO:0001741
				GO:0003673
				GO:0005575
				GO:0005622
				GO:0005623
				GO:0005737
				GO:0005739
				GO:0005759
				GO:0005763
				GO:0005779
				GO:0005824
				GO:0005967
				GO:0045254
				GO:0045265
				GO:0046612
				GO:0009656
				GO:0030085
				GO:0042648
				GO:0030671
				GO:0030688
				GO:0030692
				GO:0031358
				GO:0043229
				GO:0043231
				GO:0043226
				GO:0043227
				GO:0043234
				GO:0031616
			Descendent	GO:0005967
				GO:0045271

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