GO_term: GO:0035030   

GO:0035030	Definition	A complex containing a heterodimer of a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit bound to a SH2 domain-containing regulatory (adaptor) subunit. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.
	Term	phosphoinositide 3-kinase complex, class IA
	Type	Cellular_component
	Parent	Instance_of	GO:0005942
	Attributes_of	Index	Ancestor (19)
			Descendent	GO:0035030

Please provide feedback if you are experiencing any difficulties with this website.