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GO_term: GO:0035030   

GO:0035030DefinitionA complex containing a heterodimer of a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit bound to a SH2 domain-containing regulatory (adaptor) subunit. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.
Termphosphoinositide 3-kinase complex, class IA
TypeCellular_component
ParentInstance_ofGO:0005942
Attributes_of Index Ancestor GO:0000925
GO:0000927
GO:0003673
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005824
GO:0005829
GO:0005942
GO:0009656
GO:0012510
GO:0030085
GO:0030121
GO:0031615
GO:0031616
GO:0035030
GO:0043234
GO:0045280
DescendentGO:0035030