GO_term: GO:0019005   

GO:0019005	Definition	A protein complex usually consisting of three conserved polypeptides (named Skp1, Cdc53/Cul1, Rbx1/Hrt1 in yeast and mammals) and one variable polypeptide (F-box protein), which is involved in the targeting of proteins for proteasome degradation.
		A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome.The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
	Term	SCF ubiquitin ligase complex
	Type	Cellular_component
	Child	Instance	GO:0043223
			GO:0043224
	Parent	Instance_of	GO:0000153
			GO:0031461
	Attributes_of	Gene	F46A9.4
			Y105C5B.13
		Index	Ancestor (22)
			Descendent (6)

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