| | | [C.elegansII] b274mat : homozygous hermaphrodites produce embryos that arrest with many differentiated cells, no detectable gut granules; first cleavage symmetrical, defective P granule localization. ES3 (progeny). OA>10: it51, it90 (both missense changes in kinase domain),e2012, it32, it102, lw7 (leaky, Mes), lw39gri (deletion) etc. Cloned: 4.4 kb transcript, germline enriched, encodes predicted 1192 aa Ser/Thr kinase. Antibody staining indicates 126 kD protein with specific asymmetric membrane localizations in early blastomeres [Kemphues et al. 1988; Guo and Kemphues 1995; JJ; KK] |
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