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Gene: K04H4.1   

K04H4.1SMapS_parentSequenceK04H4
ChromosomeIII
Identity (5)
Gene_info Gene_classemb
Reference_allelehc70
Allele (14)
Phenotype hc70sd ts nn : at 25x early pretzel arrest a few animals hatch and die in L1; ts for larval growth (arrest shortly after any shift to 25x). Normal and defective execution in late embryogenesis. NA5 (all similar phenotypes : g23ts g34ts b117ts b189ts (pka zyg-6)).
[Williams BD] Pat (paralysed arrest at two-fold), late paralysis, no elongation
[C.elegansII] hc70sd,ts,nn : at 25C early pretzel arrest, a few animals hatch and die in L1; ts for larval growth (arrest shortly after any shift to 25C). Normal and defective execution in late embryogenesis. OA>10:g23ts, g34ts, b117ts, b189ts (pka zyg-6))(all similar to hc70), mj70ts (Mig, abnormal Q daughter migration).Also Pat alleles: st540, st545 (paralysed arrest at two-fold, late paralysis, no elongation).Putative nulls recessive, arrest at 3-fold stage; strong missense alleles arrest at 2-fold. Cloned: pka clb-2, encodes 1758 aa basement membrane collagen (Type IV), alpha1 chain. [Denich et al. 1984; Sibley et al. 1993; CH; MJ; RW]
Strain (9)
GO_term (8)
Contained_in_operonCEOP3574
Structured_description Provisional_description (8)
Concise_descriptionemb-9 encodes the alpha-1 chain of Type IV basement membrane collagen most closely equivalent to human COL4A1 (OMIM:120130) on the basis of biological function; EMB-9 forms heterotrimeric Type IV collagen with LET-2, the alpha-2-like chain, and is required for the assembly and/or secretion of LET-2; EMB-9 is essential for embryonic morphogenesis, particularly epidermal elongation, and for larval development; EMB-9 is expresed primarily by body wall muscles and some somatic cells of the gonad and is detected in nearly all basement membranes.
Molecular_info (6)
Experimental_info RNAi_result JA:K04H4.1
Simmer:K04H4.1
TH:320A12
Cenix:320-a12
WB_RNAi_result (5)
Expr_pattern Expr518
Expr5967
Y2H_target Y2H007361
Y2H010508
Reference (74)
RemarkData extracted from Williams & Waterston 1994
MethodGene