K04H4.1 | SMap | S_parent | Sequence | K04H4
|
| Chromosome | III |
|
Identity (5)
|
|
Gene_info
| Gene_class | emb
|
| | Reference_allele | hc70
|
| |
Allele
| b117
| Inferred_automatically | From strain object: DH117 |
| | | b189
| Inferred_automatically | From strain object: DH189 |
| | | cg34
|
| | | cg46
| Inferred_automatically | From strain object: CH1179 |
| | | cg56
| Inferred_automatically | From strain object: CH1180 |
| | | g23
|
Inferred_automatically
| From strain object: CH1179 |
| | | | | From strain object: GG23 |
| | | g23cg45
|
| | | g34
| Inferred_automatically | From strain object: GG34 |
| | | g70
|
| | | hc70
|
Inferred_automatically
| From strain object: DA589 |
| | | | | From strain object: MJ70 |
| | | st540
|
| | | st545
| Inferred_automatically | From strain object: RW3539 |
| | | uCE3-1102
|
| | | uCE3-1103
|
| |
Phenotype
| hc70sd ts nn : at 25x early pretzel arrest a few animals hatch and die in L1; ts for larval growth (arrest shortly after any shift to 25x). Normal and defective execution in late embryogenesis. NA5 (all similar phenotypes : g23ts g34ts b117ts b189ts (pka zyg-6)). |
| | | [Williams BD] Pat (paralysed arrest at two-fold), late paralysis, no elongation |
| | | [C.elegansII] hc70sd,ts,nn : at 25C early pretzel arrest, a few animals hatch and die in L1; ts for larval growth (arrest shortly after any shift to 25C). Normal and defective execution in late embryogenesis. OA>10:g23ts, g34ts, b117ts, b189ts (pka zyg-6))(all similar to hc70), mj70ts (Mig, abnormal Q daughter migration).Also Pat alleles: st540, st545 (paralysed arrest at two-fold, late paralysis, no elongation).Putative nulls recessive, arrest at 3-fold stage; strong missense alleles arrest at 2-fold. Cloned: pka clb-2, encodes 1758 aa basement membrane collagen (Type IV), alpha1 chain. [Denich et al. 1984; Sibley et al. 1993; CH; MJ; RW] |
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Strain (9)
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GO_term (8)
|
| | Contained_in_operon | CEOP3574
|
| |
Structured_description
|
Provisional_description (8)
|
| | | Concise_description | emb-9 encodes the alpha-1 chain of Type IV basement membrane collagen most closely equivalent to human COL4A1 (OMIM:120130) on the basis of biological function; EMB-9 forms heterotrimeric Type IV collagen with LET-2, the alpha-2-like chain, and is required for the assembly and/or secretion of LET-2; EMB-9 is essential for embryonic morphogenesis, particularly epidermal elongation, and for larval development; EMB-9 is expresed primarily by body wall muscles and some somatic cells of the gonad and is detected in nearly all basement membranes. |
|
Molecular_info (6)
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Experimental_info
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RNAi_result
| JA:K04H4.1
|
| | | Simmer:K04H4.1
|
| | | TH:320A12
|
| | | Cenix:320-a12
|
| |
WB_RNAi_result (5)
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| |
Expr_pattern
| Expr518
|
| | | Expr5967
|
| |
Y2H_target
| Y2H007361
|
| | | Y2H010508
|
|
Reference (74)
|
| Remark | Data extracted from Williams & Waterston 1994 |
| Method | Gene
|