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Gene: K04H4.1 
| K04H4.1 | SMap | S_parent | Sequence | K04H4 |
|---|---|---|---|---|
| Chromosome | III | |||
| Identity (5) | ||||
| Gene_info | Gene_class | emb | ||
| Reference_allele | hc70 | |||
| Allele (14) | ||||
| Phenotype | hc70sd ts nn : at 25x early pretzel arrest a few animals hatch and die in L1; ts for larval growth (arrest shortly after any shift to 25x). Normal and defective execution in late embryogenesis. NA5 (all similar phenotypes : g23ts g34ts b117ts b189ts (pka zyg-6)). | |||
| [Williams BD] Pat (paralysed arrest at two-fold), late paralysis, no elongation | ||||
| [C.elegansII] hc70sd,ts,nn : at 25C early pretzel arrest, a few animals hatch and die in L1; ts for larval growth (arrest shortly after any shift to 25C). Normal and defective execution in late embryogenesis. OA>10:g23ts, g34ts, b117ts, b189ts (pka zyg-6))(all similar to hc70), mj70ts (Mig, abnormal Q daughter migration).Also Pat alleles: st540, st545 (paralysed arrest at two-fold, late paralysis, no elongation).Putative nulls recessive, arrest at 3-fold stage; strong missense alleles arrest at 2-fold. Cloned: pka clb-2, encodes 1758 aa basement membrane collagen (Type IV), alpha1 chain. [Denich et al. 1984; Sibley et al. 1993; CH; MJ; RW] | ||||
| Strain | CH1179 | |||
| CH1180 | ||||
| DA589 | ||||
| DH117 | ||||
| DH189 | ||||
| GG23 | ||||
| GG34 | ||||
| MJ70 | ||||
| RW3539 | ||||
| GO_term (8) | ||||
| Contained_in_operon | CEOP3574 | |||
| Structured_description | Provisional_description (8) | |||
| Concise_description | emb-9 encodes the alpha-1 chain of Type IV basement membrane collagen most closely equivalent to human COL4A1 (OMIM:120130) on the basis of biological function; EMB-9 forms heterotrimeric Type IV collagen with LET-2, the alpha-2-like chain, and is required for the assembly and/or secretion of LET-2; EMB-9 is essential for embryonic morphogenesis, particularly epidermal elongation, and for larval development; EMB-9 is expresed primarily by body wall muscles and some somatic cells of the gonad and is detected in nearly all basement membranes. | |||
| Molecular_info (6) | ||||
| Experimental_info | RNAi_result | JA:K04H4.1 | ||
| Simmer:K04H4.1 | ||||
| TH:320A12 | ||||
| Cenix:320-a12 | ||||
| WB_RNAi_result (5) | ||||
| Expr_pattern | Expr518 | |||
| Expr5967 | ||||
| Y2H_target | Y2H007361 | |||
| Y2H010508 | ||||
| Reference (74) | ||||
| Remark | Data extracted from Williams & Waterston 1994 | |||
| Method | Gene |
