RNAiDB Tree View

Gene: K08E7.9

K08E7.9	SMap	S_parent	Sequence	K08E7
	Chromosome	IV
	Identity (5)
	Gene_info	Gene_class	pgp
		Allele (6)
		Phenotype	[C.elegansII] pk17 : deletion derived from pk28tci, no apparent drug sensitivity or other phenotype. Cloned: encodes 1321 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins.Transcripts relatively low, peak early;pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-1 detected in gut apical membrane. [Broeks et al. 1995; NL]
		Strain	NL130
			NL132
			NL152
		GO_term (7)
		Structured_description	Provisional_description	pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities.	Paper_evidence	WBPaper00002180
						WBPaper00003366
						WBPaper00003925
						WBPaper00005654
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities.
	Molecular_info (6)
	Experimental_info	RNAi_result	Cenix:20-a6
			JA:K08E7.9
		WB_RNAi_result	JA:K08E7.9
			Cenix:20-a6
		Expr_pattern	Expr710
			Expr1546
			Expr1548
			Expr3339
	Reference (19)
	Method	Gene