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Gene: K10B3.8   

K10B3.8SMapS_parentSequenceK10B3
ChromosomeX
Identity (5)
Gene_info Gene_classgpd
Phenotype[C.elegansII] NMK. Encodes glyceraldehyde-3-phosphate-dehydrogenase, major muscle-specific isozyme(GAPDHase-2), expression increases postembryonically .Middle gene in operon between mai-1 and gpd-3. [Barrios et al. 1989; Spieth et al. 1993; HH; BL]
GO_term (5)
Contained_in_operonCEOPX036
Structured_description Provisional_description gpd-2 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-2 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; in C. elegans, GPD-2 and GPD-3 constitute the major GAPDH isoenzymes and are expressed at highest levels during postembryonic development, primarily in the actin-containing A and I zones of body-wall muscle; loss of gpd-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities. Paper_evidence WBPaper00000730
WBPaper00001143
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
GPD-2 and GPD-3 are highly similar, exhibiting 97% identity at the amino acid level.
Concise_descriptiongpd-2 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-2 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; in C. elegans, GPD-2 and GPD-3 constitute the major GAPDH isoenzymes and are expressed at highest levels during postembryonic development, primarily in the actin-containing A and I zones of body-wall muscle; loss of gpd-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities.
Molecular_info (5)
Experimental_info RNAi_result Cenix:198-f10
Cenix:222-c1
JA:K10B3.8
WB_RNAi_result (15)
Expr_pattern Expr777
Expr6524
Y2H_targetY2H009914
Reference (30)
MethodGene