K10B3.8 | SMap | S_parent | Sequence | K10B3
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| Chromosome | X |
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Identity (5)
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Gene_info
| Gene_class | gpd
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| | Phenotype | [C.elegansII] NMK. Encodes glyceraldehyde-3-phosphate-dehydrogenase, major muscle-specific isozyme(GAPDHase-2), expression increases postembryonically .Middle gene in operon between mai-1 and gpd-3. [Barrios et al. 1989; Spieth et al. 1993; HH; BL] |
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GO_term (5)
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| | Contained_in_operon | CEOPX036
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Structured_description
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Provisional_description
| gpd-2 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-2 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; in C. elegans, GPD-2 and GPD-3 constitute the major GAPDH isoenzymes and are expressed at highest levels during postembryonic development, primarily in the actin-containing A and I zones of body-wall muscle; loss of gpd-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities. |
Paper_evidence
| WBPaper00000730
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| | | | | | WBPaper00001143
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| | | | | Person_evidence | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | GPD-2 and GPD-3 are highly similar, exhibiting 97% identity at the amino acid level. |
| | | Concise_description | gpd-2 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-2 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; in C. elegans, GPD-2 and GPD-3 constitute the major GAPDH isoenzymes and are expressed at highest levels during postembryonic development, primarily in the actin-containing A and I zones of body-wall muscle; loss of gpd-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities. |
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Molecular_info (5)
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Experimental_info
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RNAi_result
| Cenix:198-f10
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| | | Cenix:222-c1
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| | | JA:K10B3.8
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WB_RNAi_result (15)
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Expr_pattern
| Expr777
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| | | Expr6524
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| | Y2H_target | Y2H009914
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Reference (30)
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| Method | Gene
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