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Gene: LLC1.3   

LLC1.3SMapS_parentSequenceLLC1
ChromosomeIV
Identity Version1
Name (5)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:51WBPerson1971 EventImportedInitial conversion from CDS class of WS125
StatusLive
Gene_info GO_term (6)
Structured_description Provisional_description LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial.Paper_evidenceWBPaper00004424
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial.
Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile.
For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles.
By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein.
The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors.
Concise_descriptionLLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial.
Molecular_info (6)
Experimental_info RNAi_result JA:LLC1.3
Simmer:LLC1.3:Repeat_a
Simmer:LLC1.3:Screen
Cenix:54-d1
WB_RNAi_result SA:yk364e3
SA:yk391d7
JA:LLC1.3
Simmer:LLC1.3:Repeat_a
Simmer:LLC1.3:Screen
MV_SV:mv_LLC1.3
Cenix:54-d1
MethodGene