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Gene: LLC1.3 
| LLC1.3 | SMap | S_parent | Sequence | LLC1 | ||
|---|---|---|---|---|---|---|
| Chromosome | IV | |||||
| Identity (5) | ||||||
| Gene_info | GO_term | GO:0015036 | IEA | Inferred_automatically | ||
| GO:0006118 | IEA | Inferred_automatically | ||||
| GO:0016491 | IEA | Inferred_automatically | ||||
| GO:0050660 | IEA | Inferred_automatically | ||||
| GO:0004148 | IEA | Inferred_automatically | ||||
| GO:0005737 | IEA | Inferred_automatically | ||||
| Structured_description | Provisional_description | LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. | Paper_evidence | WBPaper00004424 | ||
| Person_evidence | WBPerson567 | |||||
| Curator_confirmed | WBPerson567 | |||||
| Date_last_updated | 17 Jun 2004 00:00:00 | |||||
| This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. | ||||||
| Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. | ||||||
| For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. | ||||||
| By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. | ||||||
| The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. | ||||||
| Concise_description | LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. | |||||
| Molecular_info | Corresponding_CDS | LLC1.3 | ||||
| Corresponding_CDS_history | LLC1.3:wp87 | |||||
| Corresponding_protein | WP:CE31971 | |||||
| KOG | KOG1335 | |||||
| Corresponding_PCR_product | smd_LLC1.3 | |||||
| sjj_LLC1.3 | ||||||
| Corresponding_RNAi_reagent (5) | ||||||
| Experimental_info | RNAi_result | JA:LLC1.3 | ||||
| Simmer:LLC1.3:Repeat_a | ||||||
| Simmer:LLC1.3:Screen | ||||||
| Cenix:54-d1 | ||||||
| WB_RNAi_result (7) | ||||||
| Method | Gene |
