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Gene: LLC1.3 
| LLC1.3 | SMap | S_parent | Sequence | LLC1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Chromosome | IV | ||||||||
| Identity | Version | 1 | |||||||
| Name (5) | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| Status | Live | ||||||||
| Gene_info | GO_term (6) | ||||||||
| Structured_description | Provisional_description | LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. | Paper_evidence | WBPaper00004424 | |||||
| Person_evidence | WBPerson567 | ||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. | |||||||||
| Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. | |||||||||
| For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. | |||||||||
| By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. | |||||||||
| The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. | |||||||||
| Concise_description | LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. | ||||||||
| Molecular_info | Corresponding_CDS | LLC1.3 | |||||||
| Corresponding_CDS_history | LLC1.3:wp87 | ||||||||
| Corresponding_protein | WP:CE31971 | ||||||||
| KOG | KOG1335 | ||||||||
| Corresponding_PCR_product | smd_LLC1.3 | ||||||||
| sjj_LLC1.3 | |||||||||
| Corresponding_RNAi_reagent (5) | |||||||||
| Experimental_info | RNAi_result | JA:LLC1.3 | |||||||
| Simmer:LLC1.3:Repeat_a | |||||||||
| Simmer:LLC1.3:Screen | |||||||||
| Cenix:54-d1 | |||||||||
| WB_RNAi_result | SA:yk364e3 | ||||||||
| SA:yk391d7 | |||||||||
| JA:LLC1.3 | |||||||||
| Simmer:LLC1.3:Repeat_a | |||||||||
| Simmer:LLC1.3:Screen | |||||||||
| MV_SV:mv_LLC1.3 | |||||||||
| Cenix:54-d1 | |||||||||
| Method | Gene |
