Gene: LLC1.3
LLC1.3 | SMap | S_parent | Sequence | LLC1 | ||
---|---|---|---|---|---|---|
Chromosome | IV | |||||
Identity (5) | ||||||
Gene_info | GO_term (6) | |||||
Structured_description | Provisional_description | LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. | Paper_evidence | WBPaper00004424 | ||
Person_evidence | WBPerson567 | |||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. | ||||||
Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. | ||||||
For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. | ||||||
By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. | ||||||
The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. | ||||||
Concise_description | LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. | |||||
Molecular_info (6) | ||||||
Experimental_info | RNAi_result | JA:LLC1.3 | ||||
Simmer:LLC1.3:Repeat_a | ||||||
Simmer:LLC1.3:Screen | ||||||
Cenix:54-d1 | ||||||
WB_RNAi_result | SA:yk364e3 | |||||
SA:yk391d7 | ||||||
JA:LLC1.3 | ||||||
Simmer:LLC1.3:Repeat_a | ||||||
Simmer:LLC1.3:Screen | ||||||
MV_SV:mv_LLC1.3 | ||||||
Cenix:54-d1 | ||||||
Method | Gene |