LLC1.3 | SMap | S_parent | Sequence | LLC1
|
| Chromosome | IV |
|
Identity (5)
|
|
Gene_info
|
GO_term
| GO:0015036
| IEA
| Inferred_automatically |
| | | GO:0006118
| IEA
| Inferred_automatically |
| | | GO:0016491
| IEA
| Inferred_automatically |
| | | GO:0050660
| IEA
| Inferred_automatically |
| | | GO:0004148
| IEA
| Inferred_automatically |
| | | GO:0005737
| IEA
| Inferred_automatically |
| |
Structured_description
|
Provisional_description
| LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. | Paper_evidence | WBPaper00004424
|
| | | | | Person_evidence | WBPerson567
|
| | | | | Curator_confirmed | WBPerson567
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. |
| | | | Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. |
| | | | For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. |
| | | | By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. |
| | | | The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. |
| | | Concise_description | LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD; OMIM:246900), which when mutated leads to dihydrolipoamide dehydrogenase deficiency; LLC1.3 protein is predicted to be mitochondrial. |
|
Molecular_info (6)
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|
Experimental_info
|
RNAi_result (4)
|
| |
WB_RNAi_result
| SA:yk364e3
|
| | | SA:yk391d7
|
| | | JA:LLC1.3
|
| | | Simmer:LLC1.3:Repeat_a
|
| | | Simmer:LLC1.3:Screen
|
| | | MV_SV:mv_LLC1.3
|
| | | Cenix:54-d1
|
| Method | Gene
|