RNAiDB Tree View

Gene: M7.3

M7.3	Evidence	Paper_evidence	WBPaper00005566
	SMap	S_parent	Sequence	M7
	Chromosome	IV
	Identity (5)
	Gene_info	Gene_class	bcc
		GO_term	GO:0003676	IEA	Inferred_automatically
			GO:0031177	IEA	Inferred_automatically
		Structured_description	Provisional_description	bcc-1 encodes a homolog of Drosophila and vertebrate Bicaudal C (BICC) that contains KH RNA-binding domains, a serine-rich region, and a SAM (sterile alpha motif) domain; by homology, BCC-1 is predicted to function as a cytoplasmic RNA-binding protein that is required for translational regulation and/or mRNA stability during embryonic or germline development; however, as loss of bcc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of BCC-1 in C. elegans development and/or behavior is not yet known.	Paper_evidence	WBPaper00005566
						WBPaper00005654
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
				The C. elegans genome encodes two Bicaudal C homologs: BCC-1, a more conserved homolog (in terms of domain architecture), and GLD-3, a more divergent protein that contains the KH RNA-binding domains but lacks the C-terminal SAM motif.
				Mouse BICC1 is mutated in the jcpk and bkp models of polycystic kidney disease.
			Concise_description	bcc-1 encodes a homolog of Drosophila and vertebrate Bicaudal C (BICC) that contains KH RNA-binding domains, a serine-rich region, and a SAM (sterile alpha motif) domain; by homology, BCC-1 is predicted to function as a cytoplasmic RNA-binding protein that is required for translational regulation and/or mRNA stability during embryonic or germline development; however, as loss of bcc-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of BCC-1 in C. elegans development and/or behavior is not yet known.
	Molecular_info (6)
	Experimental_info	RNAi_result (10)
		WB_RNAi_result (11)
	Reference	WBPaper00005566
	Method	Gene