RNAiDB Tree View

Gene: R05F9.8

R05F9.8	SMap	S_parent	Sequence	R05F9
	Chromosome	II
	Identity (5)
	Gene_info	Gene_class	msp
		Phenotype	[C.elegansII] NMK. Encodes MSP (16kD); msp-152 cluster. [Ward et al. (1988); BA]
		GO_term	GO:0005198	IEA	Inferred_automatically
		Structured_description	Provisional_description	msp-33 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-33 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.	Paper_evidence	WBPaper00001023
						WBPaper00002143
						WBPaper00004280
						WBPaper00004591
						WBPaper00005670
					Curator_confirmed	WBPerson324
					Date_last_updated	06 May 2005 00:00:00
			Concise_description	msp-33 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-33 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
	Molecular_info	Corresponding_CDS	R05F9.8
		Corresponding_protein	WP:CE04811
		Corresponding_PCR_product (54)
		Corresponding_RNAi_reagent (56)
	Experimental_info	RNAi_result	Cenix:211-g4
			JA:R05F9.8
			[cgc5655]:R05F9.8
			[cgc5655]:daf-2:R05F9.8
			[cgc5655]:tph-1:R05F9.8
			[cgc5655]:tub-1:R05F9.8
		WB_RNAi_result (72)
		Expr_pattern	Expr3417
	Reference	WBPaper00001023
		WBPaper00015440
		WBPaper00025088
	Method	Gene