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Gene: R06C7.8   

R06C7.8SMapS_parentSequenceR06C7
ChromosomeI
Identity (5)
Gene_info Gene_classbub
AlleleuCE1-924
GO_term GO:0004672 IEA Inferred_automatically
GO:0005524 IEA Inferred_automatically
GO:0006468 IEA Inferred_automatically
GO:0004674 IEA Inferred_automatically
Structured_description Provisional_descriptionbub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages.Paper_evidenceWBPaper00004540
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionbub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages.
Molecular_info (5)
Experimental_info RNAi_result (5)
WB_RNAi_result (6)
Expr_patternExpr175
Y2H_targetY2H005776
Reference WBPaper00024437
WBPaper00024319
RemarkSequence connection from [Oegema K, Hyman AA] [040902 ck1]
MethodGene