Gene: T04D1.3
T04D1.3 | SMap | S_parent | Sequence | T04D1 | |
---|---|---|---|---|---|
Chromosome | I | ||||
Identity (5) | |||||
Gene_info | Gene_class | unc | |||
Reference_allele | e406 | ||||
Allele (9) | |||||
Phenotype | e406 : strong kinker active small and thin; slow pharyngeal pumping; tends to hypercontract. ES3 ME2. NA4 (e590 e957 etc.). | ||||
[C.elegansII] e406 : strong kinker, active; small and thin; slow pharyngeal pumping; tends to hypercontract. ES3 ME2. OA>5: e590.e957, e1190, st199, ad592 etc. [Brenner 1974; Avery 1993; DA] | |||||
Strain | CB406 | ||||
CB1190 | |||||
DA678 | |||||
EG2710 | |||||
GO_term | GO:0005515 | IEA | Inferred_automatically | ||
GO:0005737 | IEA | Inferred_automatically | |||
Contained_in_operon | CEOP1200 | ||||
Structured_description | Provisional_description (7) | ||||
Concise_description | unc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis; UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca; like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain; UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis; unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway. | ||||
Molecular_info (6) | |||||
Experimental_info (5) | |||||
Reference (18) | |||||
Method | Gene |