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Gene: T04D1.3   

T04D1.3SMapS_parentSequenceT04D1
ChromosomeI
Identity (5)
Gene_info Gene_classunc
Reference_allelee406
Allele (9)
Phenotype e406 : strong kinker active small and thin; slow pharyngeal pumping; tends to hypercontract. ES3 ME2. NA4 (e590 e957 etc.).
[C.elegansII] e406 : strong kinker, active; small and thin; slow pharyngeal pumping; tends to hypercontract. ES3 ME2. OA>5: e590.e957, e1190, st199, ad592 etc. [Brenner 1974; Avery 1993; DA]
Strain CB406
CB1190
DA678
EG2710
GO_term GO:0005515 IEA Inferred_automatically
GO:0005737 IEA Inferred_automatically
Contained_in_operonCEOP1200
Structured_description Provisional_description (7)
Concise_descriptionunc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis; UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca; like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain; UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis; unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway.
Molecular_info (6)
Experimental_info (5)
Reference (18)
MethodGene