Gene: T04D1.3
T04D1.3 | SMap | S_parent | Sequence | T04D1 | |||||
---|---|---|---|---|---|---|---|---|---|
Chromosome | I | ||||||||
Identity | Version | 1 | |||||||
Name (7) | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Gene_class | unc | |||||||
Reference_allele | e406 | ||||||||
Allele (9) | |||||||||
Phenotype | e406 : strong kinker active small and thin; slow pharyngeal pumping; tends to hypercontract. ES3 ME2. NA4 (e590 e957 etc.). | ||||||||
[C.elegansII] e406 : strong kinker, active; small and thin; slow pharyngeal pumping; tends to hypercontract. ES3 ME2. OA>5: e590.e957, e1190, st199, ad592 etc. [Brenner 1974; Avery 1993; DA] | |||||||||
Strain | CB406 | ||||||||
CB1190 | |||||||||
DA678 | |||||||||
EG2710 | |||||||||
GO_term | GO:0005515 | IEA | Inferred_automatically | ||||||
GO:0005737 | IEA | Inferred_automatically | |||||||
Contained_in_operon | CEOP1200 | ||||||||
Structured_description | Provisional_description (7) | ||||||||
Concise_description | unc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis; UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca; like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain; UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis; unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway. | ||||||||
Molecular_info (6) | |||||||||
Experimental_info (5) | |||||||||
Reference (18) | |||||||||
Method | Gene |