Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 

Gene: T05G5.3   

T05G5.3EvidenceCGC_data_submission
SMapS_parentSequenceT05G5
ChromosomeIII
Identity (5)
Gene_info Gene_classcdk
Allele (7)
Phenotype[C.elegansII] NMK. Encodes 38 kD protein, homolog of fission yeast p34 cdc2 kinase, 65% identity to human cdc2 but has sequence PSTAVR rather than PSTAIR; can complement some alleles of budding yeast CDC28. [Mori et al. 1994; PS]
Strain (5)
GO_term (9)
Structured_description Provisional_description cdk-1 encodes a cyclin-dependent kinase, orthologous to and functionally interchangeable with CDC28 from S. cerevisiae; CDK-1 is required for cell-cycle progression through M phase in both meiosis and mitosis. Paper_evidence WBPaper00002097
WBPaper00003554
WBPaper00004192
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
While maternal ncc-1 product is sufficient for embryogenesis, zygotic expression is required for cell divisions during larval development.
CDK-1 falls into an orthologous group of cyclin-dependent kinases that includes CDC28 from S. cerevisiae, cdc2 from S. pombe, and CDK1-3 from human beings.
Concise_descriptioncdk-1 encodes a cyclin-dependent kinase, orthologous to and functionally interchangeable with CDC28 from S. cerevisiae; CDK-1 is required for cell-cycle progression through M phase in both meiosis and mitosis.
Molecular_info (6)
Experimental_info RNAi_result (8)
WB_RNAi_result TH:321b3
JA:T05G5.3
[cgc5224]:cdk-1
Simmer:T05G5.3
MV_SV:mv_T05G5.3
Cenix:321-b3
Cenix:341-e4
PF:GL1_6A3
Expr_pattern Expr551
Expr1328
Y2H_baitY2H011508
Reference (36)
Remark Sequence connection from [Golden A]
old_name ncc-1 becomes new_name cdk-1 from [Golden A].
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene