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Gene: T07D4.3   

T07D4.3EvidenceCGC_data_submission
SMapS_parentSequenceT07D4
ChromosomeII
Identity Version1
Name (7)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971 EventImportedInitial conversion from geneace
StatusLive
Gene_info Gene_classrha
Allele tm329
cxP3605
GO_term (5)
Structured_description Provisional_description rha-1 encodes an ATP-dependent DEAD/H box RNA helicase orthologous to human RNA helicase A and Drosophila Maleless, an essential component of the dosage compensation machinery required for increased X-linked transcription in males; by homology, RHA-1 is predicted to function in regulation of transcription, translation, RNA processing, and/or RNA replication; in C. elegans, RHA-1 is required for germ cell proliferation, normal germ cell nuclear morphology, RNA-mediated interference (RNAi) of germline-expressed genes, and silencing of germline-expressed transgenes; RHA-1 is reported to localize to the nucleus and the cytoplasm. Paper_evidence WBPaper00004587
WBPaper00005486
WBPaper00018735
WBPaper00019034
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
MALELESS DEAH helicases, in Drosophila, are part of a complex of proteins (including DEAH helicase and MYST acetyltransferases) and RNAs called the 'compensasome' that mediates dosage compensation.
RHA-1, fly MLE, and their orthologs in other metazoans have acquired new protein domains since the divergence of fungi and animals.
The components of the compensasome are generally conserved in metazoa: they thus are likely to act as a functional unit in C. elegans and other metazoa, and not merely in Drosophila alone.
Concise_descriptionrha-1 encodes an ATP-dependent DEAD/H box RNA helicase orthologous to human RNA helicase A and Drosophila Maleless, an essential component of the dosage compensation machinery required for increased X-linked transcription in males; by homology, RHA-1 is predicted to function in regulation of transcription, translation, RNA processing, and/or RNA replication; in C. elegans, RHA-1 is required for germ cell proliferation, normal germ cell nuclear morphology, RNA-mediated interference (RNAi) of germline-expressed genes, and silencing of germline-expressed transgenes; RHA-1 is reported to localize to the nucleus and the cytoplasm.
Molecular_info (5)
Experimental_info RNAi_result Cenix:202-a4
JA:T07D4.3
PF:GL1_2D11
WB_RNAi_result SA:yk384b11
JA:T07D4.3
Cenix:202-a4
PF:GL1_2D11
Expr_pattern Expr3232
Expr3233
Reference (7)
Remark Sequence connection from [Walstrom KM]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene