T07D4.3 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | T07D4
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| Chromosome | II |
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Identity (5)
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Gene_info
| Gene_class | rha
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Allele (2)
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GO_term (5)
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Structured_description
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Provisional_description
| rha-1 encodes an ATP-dependent DEAD/H box RNA helicase orthologous to human RNA helicase A and Drosophila Maleless, an essential component of the dosage compensation machinery required for increased X-linked transcription in males; by homology, RHA-1 is predicted to function in regulation of transcription, translation, RNA processing, and/or RNA replication; in C. elegans, RHA-1 is required for germ cell proliferation, normal germ cell nuclear morphology, RNA-mediated interference (RNAi) of germline-expressed genes, and silencing of germline-expressed transgenes; RHA-1 is reported to localize to the nucleus and the cytoplasm. |
Paper_evidence
| WBPaper00004587
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| | | | | | WBPaper00005486
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| | | | | | WBPaper00018735
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| | | | | | WBPaper00019034
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| | | | | Person_evidence | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | MALELESS DEAH helicases, in Drosophila, are part of a complex of proteins (including DEAH helicase and MYST acetyltransferases) and RNAs called the 'compensasome' that mediates dosage compensation. |
| | | | RHA-1, fly MLE, and their orthologs in other metazoans have acquired new protein domains since the divergence of fungi and animals. |
| | | | The components of the compensasome are generally conserved in metazoa: they thus are likely to act as a functional unit in C. elegans and other metazoa, and not merely in Drosophila alone. |
| | | Concise_description | rha-1 encodes an ATP-dependent DEAD/H box RNA helicase orthologous to human RNA helicase A and Drosophila Maleless, an essential component of the dosage compensation machinery required for increased X-linked transcription in males; by homology, RHA-1 is predicted to function in regulation of transcription, translation, RNA processing, and/or RNA replication; in C. elegans, RHA-1 is required for germ cell proliferation, normal germ cell nuclear morphology, RNA-mediated interference (RNAi) of germline-expressed genes, and silencing of germline-expressed transgenes; RHA-1 is reported to localize to the nucleus and the cytoplasm. |
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Molecular_info (5)
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Experimental_info
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RNAi_result
| Cenix:202-a4
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| | | JA:T07D4.3
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| | | PF:GL1_2D11
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WB_RNAi_result (4)
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Expr_pattern
| Expr3232
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| | | Expr3233
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Reference (7)
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Remark
| Sequence connection from [Walstrom KM] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene
|