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Gene: T10G3.6   

T10G3.6EvidencePerson_evidenceWBPerson1846
SMapS_parentSequenceT10G3
ChromosomeV
Identity (5)
Gene_info Gene_classgut
Allele it92
lw6
gk407 Inferred_automaticallyFrom strain object: VC904
gk402 Inferred_automaticallyFrom strain object: VC989
Phenotype [C.elegansII] lw6 : E cells fail to gastrulate, division rate does not slow; mutant EMS not responsive to WT P2 induction. lw6/Df similar. OA>10: it92, lw63 (Gro, sterile). Cloned: cosmid rescue (T10G8). [EH; CB]
[Shaw JE] lw6 and it92 are not null alleles. lw6 and it92 are recessive, strict maternal effect lethal. Dead embryos arrest development with approximately normal cell number but no morphogenesis. Dead embryos are highly penetrant for lack of both differentiated gut cells and pharyngeal muscle. Other tissues (hypodermal, neuronal, body-wall muscle) are present. Early defects in E lineage,i.e. early 2E to 4E division and failure to gastrulate, highly penetrant. Null phenotype likely recessive slow-growing, sterile adult.
Strain VC904
VC989
GO_term GO:0006397 IEA Inferred_automatically
GO:0030529 IEA Inferred_automatically
GO:0005634 IEA Inferred_automatically
GO:0005732 IEA Inferred_automatically
Structured_description Provisional_descriptiongut-2 encodes a member of the Sm protein family with highest similarity to human U6 snRNA-associated Sm-like protein, LSm2, that affects embryonic viability. Paper_evidence WBPaper00012624
WBPaper00023072
Person_evidenceWBPerson48
Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptiongut-2 encodes a member of the Sm protein family with highest similarity to human U6 snRNA-associated Sm-like protein, LSm2, that affects embryonic viability.
Molecular_info Corresponding_CDST10G3.6
Corresponding_CDS_historyT10G3.6:wp138
Corresponding_proteinWP:CE37990
KOGKOG3448
Corresponding_PCR_product smd_T10G3.6
sjj_T10G3.6
Corresponding_RNAi_reagent Cenix:104-h10
sjj_T10G3.6
Experimental_info RNAi_result JA:T10G3.6
Simmer:T10G3.6:Repeat_a
Simmer:T10G3.6:Screen
Cenix:104-h10
WB_RNAi_result JA:T10G3.6
Simmer:T10G3.6:Repeat_a
Simmer:T10G3.6:Screen
Cenix:104-h10
Reference (6)
RemarkThe gut-2 gene was merged with lsm-2 following advice from the CGC. gut-2 is the main name for this gene.CGC_data_submission
MethodGene