RNAiDB Tree View

Gene: T12A7.1

T12A7.1	Evidence	Paper_evidence	WBPaper00006177
	SMap	S_parent	Sequence	T12A7
	Chromosome	IV
	Identity (5)
	Gene_info	Gene_class	gem
		Allele (8)
		Strain	EJ808
			RB974
			VC415
		Structured_description	Provisional_description	gem-4 encodes a Ca[2+]-dependent phosphatidylserine binding protein (copine) that antagonizes GON-2 in gonadal cell division, with no other obvious function in normal animals; GEM-4 is highly similar to three human proteins, copine I, copine III, and KIA1599 (40% identity over 590 residues); GEM-4 is also similar to its C. elegans paralog, F26D10.4 (73% identity over 637 residues), with at least three other copines being encoded by the C. elegans genome; since both GEM-4 and GON-2 are predicted to be plasma membrane proteins, they may interact directly.	Paper_evidence	WBPaper00006177
						WBPaper00013609
						WBPaper00013620
						WBPaper00013621
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				All copines have two 130-residue C2 domains in the N-terminal half of the protein; C2 domains are found in many different proteins and typically mediate binding to Ca[2+]; and the C-terminal half of copine proteins contains an A domain of 200 aa that has similarity to the Mg[2+]-binding domain of integrins.
				Mutations in gem-4 suppress loss-of-function alleles of gon-2, but not alleles of gon-4, indicating that gon-4 activity is either downstream of or parallel to the activity of gem-4 and gon-2; gem-4 mutations have no obvious phenotype in a wild-type background.
			Concise_description	gem-4 encodes a Ca[2+]-dependent phosphatidylserine binding protein (copine) that antagonizes GON-2 in gonadal cell division, with no other obvious function in normal animals; GEM-4 is highly similar to three human proteins, copine I, copine III, and KIA1599 (40% identity over 590 residues); GEM-4 is also similar to its C. elegans paralog, F26D10.4 (73% identity over 637 residues), with at least three other copines being encoded by the C. elegans genome; since both GEM-4 and GON-2 are predicted to be plasma membrane proteins, they may interact directly.
	Molecular_info (5)
	Experimental_info (5)
	Reference	WBPaper00018419
		WBPaper00006177
	Remark	data extracted by jah from PMID 14573470	CGC_data_submission
		Postitive method is mutant sequence	CGC_data_submission
	Method	Gene