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Gene: T14A8.1   

T14A8.1EvidenceCGC_data_submission
SMapS_parentSequenceT14A8
ChromosomeIV
Identity Version1
Name (7)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971 EventImportedInitial conversion from geneace
StatusLive
Gene_info Gene_classric
Allele (9)
Phenotype (2)
Strain MF200
RM509
Structured_description Provisional_description The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.Paper_evidenceWBPaper00005151
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
However, GABA and glutamate receptors, despite being coexpressed with ric-3-dependent nicotinic acetylcholine receptors, are unaffected by mutation of ric-3.
Mutations in ric-3 mutants are resistant to inhibitors of cholinesterase and suppress neurodegeneration caused by a gain-of-function deg-3 mutation.
Coexpression of ric-3 in Xenopus laevis oocytes enhances the activity of the C.elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors.
Concise_descriptionThe ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.
Molecular_info Corresponding_CDST14A8.1
Corresponding_proteinWP:CE27448
Corresponding_PCR_product (2)
Corresponding_RNAi_reagent (4)
Experimental_info RNAi_result (5)
WB_RNAi_result (7)
Expr_patternExpr1841
Interaction WBInteraction0001603
WBInteraction0001604
WBInteraction0001898
WBInteraction0002829
Reference (14)
Remark (2)
MethodGene