Gene: T14A8.1
T14A8.1 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T14A8 | ||||||
Chromosome | IV | ||||||||
Identity | Version | 1 | |||||||
Name (7) | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Gene_class | ric | |||||||
Allele | hm9 | Inferred_automatically | From strain object: MF200 | ||||||
hm19 | |||||||||
hm54 | |||||||||
hm65 | |||||||||
md146 | |||||||||
md156 | |||||||||
md158 | Inferred_automatically | From strain object: RM509 | |||||||
md226 | |||||||||
md1181 | |||||||||
Phenotype (2) | |||||||||
Strain | MF200 | ||||||||
RM509 | |||||||||
Structured_description | Provisional_description | The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. | Paper_evidence | WBPaper00005151 | |||||
Person_evidence | WBPerson567 | ||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
However, GABA and glutamate receptors, despite being coexpressed with ric-3-dependent nicotinic acetylcholine receptors, are unaffected by mutation of ric-3. | |||||||||
Mutations in ric-3 mutants are resistant to inhibitors of cholinesterase and suppress neurodegeneration caused by a gain-of-function deg-3 mutation. | |||||||||
Coexpression of ric-3 in Xenopus laevis oocytes enhances the activity of the C.elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors. | |||||||||
Concise_description | The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. | ||||||||
Molecular_info | Corresponding_CDS | T14A8.1 | |||||||
Corresponding_protein | WP:CE27448 | ||||||||
Corresponding_PCR_product (2) | |||||||||
Corresponding_RNAi_reagent (4) | |||||||||
Experimental_info (4) | |||||||||
Reference | WBPaper00015580 | ||||||||
WBPaper00002590 | |||||||||
WBPaper00017986 | |||||||||
WBPaper00023190 | |||||||||
WBPaper00002195 | |||||||||
WBPaper00002297 | |||||||||
WBPaper00005594 | |||||||||
WBPaper00005687 | |||||||||
WBPaper00018129 | |||||||||
WBPaper00023449 | |||||||||
WBPaper00006324 | |||||||||
WBPaper00025141 | |||||||||
WBPaper00025716 | |||||||||
WBPaper00026764 | |||||||||
Remark (2) | |||||||||
Method | Gene |