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Gene: T14A8.1   

T14A8.1EvidenceCGC_data_submission
SMapS_parentSequenceT14A8
ChromosomeIV
Identity (5)
Gene_info Gene_classric
Allele hm9 Inferred_automaticallyFrom strain object: MF200
hm19
hm54
hm65
md146
md156
md158 Inferred_automaticallyFrom strain object: RM509
md226
md1181
Phenotype (2)
Strain MF200
RM509
Structured_description Provisional_description The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.Paper_evidenceWBPaper00005151
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
However, GABA and glutamate receptors, despite being coexpressed with ric-3-dependent nicotinic acetylcholine receptors, are unaffected by mutation of ric-3.
Mutations in ric-3 mutants are resistant to inhibitors of cholinesterase and suppress neurodegeneration caused by a gain-of-function deg-3 mutation.
Coexpression of ric-3 in Xenopus laevis oocytes enhances the activity of the C.elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors.
Concise_descriptionThe ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.
Molecular_info (4)
Experimental_info (4)
Reference WBPaper00015580
WBPaper00002590
WBPaper00017986
WBPaper00023190
WBPaper00002195
WBPaper00002297
WBPaper00005594
WBPaper00005687
WBPaper00018129
WBPaper00023449
WBPaper00006324
WBPaper00025141
WBPaper00025716
WBPaper00026764
Remark (2)
MethodGene