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Gene: T14A8.1   

T14A8.1EvidenceCGC_data_submission
SMapS_parentSequenceT14A8
ChromosomeIV
Identity (5)
Gene_info Gene_classric
Allele hm9 Inferred_automaticallyFrom strain object: MF200
hm19
hm54
hm65
md146
md156
md158 Inferred_automaticallyFrom strain object: RM509
md226
md1181
Phenotype (2)
Strain (2)
Structured_description Provisional_description The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.Paper_evidenceWBPaper00005151
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
However, GABA and glutamate receptors, despite being coexpressed with ric-3-dependent nicotinic acetylcholine receptors, are unaffected by mutation of ric-3.
Mutations in ric-3 mutants are resistant to inhibitors of cholinesterase and suppress neurodegeneration caused by a gain-of-function deg-3 mutation.
Coexpression of ric-3 in Xenopus laevis oocytes enhances the activity of the C.elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors.
Concise_descriptionThe ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.
Molecular_info Corresponding_CDST14A8.1
Corresponding_proteinWP:CE27448
Corresponding_PCR_product smd_T14A8.1
sjj_T14A8.1
Corresponding_RNAi_reagent (4)
Experimental_info RNAi_result Cenix:105-c4
JA:T14A8.1
[cgc5655]:T14A8.1
[cgc5655]:tph-1:T14A8.1
[cgc5655]:tub-1:T14A8.1
WB_RNAi_result (7)
Expr_patternExpr1841
Interaction WBInteraction0001603
WBInteraction0001604
WBInteraction0001898
WBInteraction0002829
Reference (14)
Remark previously appeared as des-5
Sequence connection from [Halevi S, Treinin M]
MethodGene