RNAiDB Tree View

Gene: T20B12.2

T20B12.2	SMap	S_parent	Sequence	T20B12
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	tbp
		Allele	ok185	Inferred_automatically	From strain object: SM942
			snp_T20B12[1]
			snp_T20B12[2]
			uCE3-1010
		Phenotype	NMK. Encodes 340 aa protein, 85% identity to human TBP in C-term half; recombinantTBP-1 binds hsp-16 TATA box. [Lichsteiner and Tjian 1993]
		Strain	SM942
		GO_term (7)
		Contained_in_operon	CEOP3436
		Structured_description	Provisional_description	tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth.	Paper_evidence (7)
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth.
	Molecular_info (6)
	Experimental_info	RNAi_result (6)
		WB_RNAi_result (7)
		Y2H_target (21)
	Reference	WBPaper00006475
		WBPaper00014577
		WBPaper00014579
		WBPaper00001823
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene