RNAiDB Tree View

Gene: T20H4.4

T20H4.4	Evidence	Paper_evidence	WBPaper00005596
	SMap	S_parent	Sequence	SUPERLINK_RW3B
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	adr
		Allele	gv42	Paper_evidence	WBPaper00005596
				Inferred_automatically	From strain object: BB3
					From strain object: BB4
			ok735	Inferred_automatically	From strain object: RB886
			tm670
			CE3-159
		Strain	BB3
			BB4
			RB886
		GO_term (5)
		Contained_in_operon	CEOP3424
		Structured_description	Provisional_description	adr-2 encodes an adenosine deaminase that acts on RNA (ADAR); ADARs are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA); adr-2 is expressed ubiquitously in early embryos, as well as in the germline of early adults; ADR-2 is required for ADAR activity in vivo, and for normal chemotaxis.	Paper_evidence (8)
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				adr-2(gv42) mutants show no ADAR activity either in vitro (from extracts of mixed-stage whole worms) on an artificial substrate, or in vivo on 256 sites of ADAR action on natural mRNA substrates.
				Despite the complete loss of ADAR activity in adr-2(gv42) mutants, they display normal vulval development, in contrast to adr-1(gv6) mutants which show a mix of partial ADAR loss and partial ADAR hyperactivity.
				The putative catalytic site of ADR-1 is divergent from the consensus sequence found in most ADARs (including ADR-2), which suggests that ADR-1 might form a catalytically inactive heteromeric subunit with ADR-2.
			Concise_description	adr-2 encodes an adenosine deaminase that acts on RNA (ADAR); ADARs are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA); adr-2 is expressed ubiquitously in early embryos, as well as in the germline of early adults; ADR-2 is required for ADAR activity in vivo, and for normal chemotaxis.
	Molecular_info (5)
	Experimental_info	RNAi_result	Cenix:305-b3
			JA:T20H4.4
			TH:305B3
		WB_RNAi_result	TH:305B3
			JA:T20H4.4
			MV_SV:mv_AAC25097
			Cenix:305-b3
		Y2H_bait	Y2H002211
			Y2H002213
		Y2H_target	Y2H009400
	Reference (6)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene