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Gene: W02A11.4   

W02A11.4SMapS_parentSequenceW02A11
ChromosomeI
Identity (5)
Gene_info Gene_classuba
AlleleuCE1-1375
GO_term (5)
Structured_description Provisional_description uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. Paper_evidence WBPaper00005337
WBPaper00006514
WBPaper00023983
Curator_confirmedWBPerson1843
Date_last_updated27 Jan 2005 00:00:00
In addition, uba-2 and aos-1 may also play a role in fate specification of the VD (ventral D) GABAergic motor neurons, as reduction of uba-2 or aos-1 activity results in ectopic expression of a DD (dorsal D)-specific reporter in the VD neurons.
Concise_descriptionuba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
Molecular_info (6)
Experimental_info RNAi_result JA:W02A11.4
Simmer:W02A11.4:Screen_A
Simmer:W02A11.4:Screen_B
Cenix:76-c5
WB_RNAi_result (5)
Reference WBPaper00005337
WBPaper00006514
WBPaper00023983
WBPaper00026636
Remark Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb.
W02A11.4a/b isoforms are no longer validPerson_evidenceWBPerson1847
MethodGene