RNAiDB Tree View

Gene: W03C9.7

W03C9.7	SMap	S_parent	Sequence	SUPERLINK_CB_II
	Chromosome	II
	Identity (5)
	Gene_info	Gene_class	mex
		Reference_allele	it9
		Allele (10)
		Phenotype	[Draper BW] Maternal effect lethal mutation which results in the four AB granddaughters of the eight cell stage embryo following a pattern of development nearly identical to the posterior blastomere MS. This results in embryos which produce excess muscle and pharynx.
			[C.elegansII] zu121 : maternal effect lethal mutation, which results in four AB granddaughters of the eight cell stage embryo following a pattern of development nearly identical to the posterior blastomere MS. This results in embryos which produce excess muscle and pharynx. OA9: zu120, zu122, zu140, zu173, zu221it9 (pka mel-21)[Mello et al. 1992; JJ; KK]
		Strain	JJ529
			KK337
		GO_term (7)
		Structured_description	Provisional_description	The mex-1 gene encodes a CCCH-type zinc-finger protein that is required maternally for segregation of P granules, germ cell formation, and somatic cell differentiation in the early embryo; mex-1 is expressed cytoplasmically in germ line blastomeres and is required for restricting PIE-1 expression and function to these cells; mex-1 RNA is also found transiently in association with P granules.	Paper_evidence (5)
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
				mex-1 is believed to function as a link between cortical polarity established by the par genes and subsequent differential segregation of cytoplasmic determinants.
			Concise_description	The mex-1 gene encodes a CCCH-type zinc-finger protein that is required maternally for segregation of P granules, germ cell formation, and somatic cell differentiation in the early embryo; mex-1 is expressed cytoplasmically in germ line blastomeres and is required for restricting PIE-1 expression and function to these cells; mex-1 RNA is also found transiently in association with P granules.
	Molecular_info (7)
	Experimental_info	RNAi_result	PF:GL1_6A11
			Cenix:50-c2
			Cenix:54-g3
		WB_RNAi_result	PF:GL1_6A11
			Cenix:50-c2
			Cenix:54-g3
		Expr_pattern	Expr576
			Expr577
		Y2H_target	Y2H011221
		Interaction	WBInteraction0003116
			WBInteraction0003187
	Reference (85)
	Method	Gene