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Gene: W03D2.4   

W03D2.4EvidenceCGC_data_submission
SMapS_parentSequenceSUPERLINK_RW4
ChromosomeIV
Identity (5)
Gene_info Gene_classpcn
GO_term (5)
Structured_description Provisional_descriptionpcn-1 encodes the C. elegans ortholog of proliferating cell nuclear antigen (PCNA), an acidic protein that is an essential component of the DNA replication and repair machinery and serves as a processivity factor for DNA polymerase delta; PCN-1 is required for early embryogenesis and for proper germ-line development, and directly interacts with CKI-2, a cyclin-dependent kinase inhibitor homolog that may be required for cell cycle progression during embryogenesis, and with ATL-1/PI3K, KIN-20, MRT-2/RAD1, and RFC-1, proteins that all play a role in the DNA damage checkpoint pathway; PCN-1 is highly expressed in ovaries and developing embryos. Paper_evidence WBPaper00004540
WBPaper00005039
WBPaper00018634
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionpcn-1 encodes the C. elegans ortholog of proliferating cell nuclear antigen (PCNA), an acidic protein that is an essential component of the DNA replication and repair machinery and serves as a processivity factor for DNA polymerase delta; PCN-1 is required for early embryogenesis and for proper germ-line development, and directly interacts with CKI-2, a cyclin-dependent kinase inhibitor homolog that may be required for cell cycle progression during embryogenesis, and with ATL-1/PI3K, KIN-20, MRT-2/RAD1, and RFC-1, proteins that all play a role in the DNA damage checkpoint pathway; PCN-1 is highly expressed in ovaries and developing embryos.
Molecular_info (6)
Experimental_info RNAi_result Cenix:29-h8
PF:GL1_1C4
WB_RNAi_result Cenix:29-h8
PF:GL1_1C4
Y2H_target Y2H008602
Y2H008606
Reference WBPaper00006017
WBPaper00018634
WBPaper00026640
RemarkSequence connection from [Boulton S, Vidal M]
MethodGene