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Gene: W04B5.5   

W04B5.5SMapS_parentSequenceW04B5
ChromosomeIII
Identity (5)
Gene_info Alleleok1309 Inferred_automaticallyFrom strain object: RB1244
StrainRB1244
GO_term GO:0004672 IEA Inferred_automatically
GO:0005524 IEA Inferred_automatically
GO:0006468 IEA Inferred_automatically
GO:0004674 IEA Inferred_automatically
Contained_in_operonCEOP3076
Structured_description Provisional_description The W04B5.5 gene encodes a phospholipid-independent AKT/PKB kinase.Paper_evidenceWBPaper00004720
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
It is paralogous to H42K12.1, the C. elegans ortholog of 3-phosphoinositide dependent kinase 1 (PDK1), but lacks a phospholipid binding pleckstrin homology domain found in PDK-1.
W04B5.5 phosphorylates mammalian AKT/PKB at an activating Thr(308) residue despite the presence of phosphatidylinositol (PI) 3-kinase inhibitors; W04B5.5 is also able to induce phospholipid-independent phosphorylation of an AFX-type forkhead transcription factor, which converts it to an inactive cytoplasmic form; because the transcription factor is proapoptotic in the nucleus, the W04B5.5 gene may encode an antiapoptotic protein.
W04B5.5 activity appears to be induced by agents that inhibit cell cycle G(1) progression.
Concise_descriptionThe W04B5.5 gene encodes a phospholipid-independent AKT/PKB kinase.
Molecular_info (5)
Experimental_info RNAi_result Cenix:330-g2
JA:W04B5.5
TH:330G2
WB_RNAi_result TH:330G2
JA:W04B5.5
MV_SV:mv_W04B5.5
Cenix:330-g2
MethodGene