Gene: W04B5.5
W04B5.5 | SMap | S_parent | Sequence | W04B5 | ||
---|---|---|---|---|---|---|
Chromosome | III | |||||
Identity (5) | ||||||
Gene_info | Allele | ok1309 | Inferred_automatically | From strain object: RB1244 | ||
Strain | RB1244 | |||||
GO_term | GO:0004672 | IEA | Inferred_automatically | |||
GO:0005524 | IEA | Inferred_automatically | ||||
GO:0006468 | IEA | Inferred_automatically | ||||
GO:0004674 | IEA | Inferred_automatically | ||||
Contained_in_operon | CEOP3076 | |||||
Structured_description | Provisional_description | The W04B5.5 gene encodes a phospholipid-independent AKT/PKB kinase. | Paper_evidence | WBPaper00004720 | ||
Person_evidence | WBPerson567 | |||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
It is paralogous to H42K12.1, the C. elegans ortholog of 3-phosphoinositide dependent kinase 1 (PDK1), but lacks a phospholipid binding pleckstrin homology domain found in PDK-1. | ||||||
W04B5.5 phosphorylates mammalian AKT/PKB at an activating Thr(308) residue despite the presence of phosphatidylinositol (PI) 3-kinase inhibitors; W04B5.5 is also able to induce phospholipid-independent phosphorylation of an AFX-type forkhead transcription factor, which converts it to an inactive cytoplasmic form; because the transcription factor is proapoptotic in the nucleus, the W04B5.5 gene may encode an antiapoptotic protein. | ||||||
W04B5.5 activity appears to be induced by agents that inhibit cell cycle G(1) progression. | ||||||
Concise_description | The W04B5.5 gene encodes a phospholipid-independent AKT/PKB kinase. | |||||
Molecular_info (5) | ||||||
Experimental_info | RNAi_result | Cenix:330-g2 | ||||
JA:W04B5.5 | ||||||
TH:330G2 | ||||||
WB_RNAi_result | TH:330G2 | |||||
JA:W04B5.5 | ||||||
MV_SV:mv_W04B5.5 | ||||||
Cenix:330-g2 | ||||||
Method | Gene |