RNAiDB Tree View

Gene: W09D6.6

W09D6.6	SMap	S_parent	Sequence	W09D6
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	hmt
		Allele	gk155	Inferred_automatically	From strain object: VC252
			gk161	Inferred_automatically	From strain object: VC287
		Strain	VC252
			VC287
		GO_term (7)
		Structured_description	Provisional_description	haf-5 encodes a predicted transmembrane half-molecule ATP-binding cassette (ABC) transporter orthologous to Schizosaccharomyces pombe heavy metal tolerance factor 1 (SpHMT1), an ATP-dependent phytochelatin transporter; HAF-5 is required for cadmium detoxification and by homology, is predicted to promote sequestration of heavy metal-containing phytochelatins into intracellular vacuoles to protect cells from potential damage.	Paper_evidence	WBPaper00004424
						WBPaper00010614
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
				Expression of haf-5 in S. pombe is able to rescue the cadmium-hypersensitivity of hmt1- mutants.
				This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial.
			Concise_description	haf-5 encodes a predicted transmembrane half-molecule ATP-binding cassette (ABC) transporter orthologous to Schizosaccharomyces pombe heavy metal tolerance factor 1 (SpHMT1), an ATP-dependent phytochelatin transporter; HAF-5 is required for cadmium detoxification and by homology, is predicted to promote sequestration of heavy metal-containing phytochelatins into intracellular vacuoles to protect cells from potential damage.
	Molecular_info (7)
	Experimental_info	RNAi_result	JA:W09D6.5
			Cenix:321-d8
			TH:321D8
		WB_RNAi_result	TH:321D8
			MV_SV:mv_W09D6.6
			Cenix:321-d8
		Expr_pattern	Expr3355
			Expr5761
	Reference	WBPaper00025092
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene