W10C8.2 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | W10C8
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| Chromosome | I |
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Identity (5)
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Gene_info
| Gene_class | pop
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Allele
| hu9
| Inferred_automatically | From strain object: KN562 |
| | | q624
| Inferred_automatically | From strain object: JK2945 |
| | | q645
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Inferred_automatically
| From strain object: JK2689 |
| | | | | From strain object: JK2782 |
| | | | | From strain object: JK2944 |
| | | zu189
| Inferred_automatically | From strain object: JJ1057 |
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Phenotype
| [Lin R] Pop (posterior pharynx defective) phenotype: maternal lethal, causing MS blastomere to adopt the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. zu189 isolated in mutator background, probable Tc1 insertion. |
| | | [C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells; MS blastomere adopts the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995; JJ] |
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Strain (6)
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GO_term (11)
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Structured_description
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Provisional_description (7)
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Concise_description
| pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva. |
| | | | The pop-1 gene encodes a homolog of Drosophila PANGOLIN; POP-1 is required for proper polarity in both early embryos and postembryonic development. |
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Molecular_info (6)
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Experimental_info (6)
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Reference (156)
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Remark
| Datum extracted from Lin et al. (1995). |
| | [Lin R] zu189 is Tc1 insertion allele, Tc1 mapped to BF8 + |
| | Sequence connection from [Lin R, Thompson S, Priess JR], [krb 020702] |
| | old_name sys-2 becomes new_name pop-1 from [Kimble JE]. |
| Method | Gene
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