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Gene: W10C8.2   

W10C8.2EvidenceCGC_data_submission
SMapS_parentSequenceW10C8
ChromosomeI
Identity (5)
Gene_info Gene_classpop
Allele hu9 Inferred_automaticallyFrom strain object: KN562
q624 Inferred_automaticallyFrom strain object: JK2945
q645 Inferred_automatically From strain object: JK2689
From strain object: JK2782
From strain object: JK2944
zu189 Inferred_automaticallyFrom strain object: JJ1057
Phenotype [Lin R] Pop (posterior pharynx defective) phenotype: maternal lethal, causing MS blastomere to adopt the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. zu189 isolated in mutator background, probable Tc1 insertion.
[C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells; MS blastomere adopts the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995; JJ]
Strain (6)
GO_term (11)
Structured_description Provisional_description (7)
Concise_description pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.
The pop-1 gene encodes a homolog of Drosophila PANGOLIN; POP-1 is required for proper polarity in both early embryos and postembryonic development.
Molecular_info (6)
Experimental_info (6)
Reference (156)
Remark Datum extracted from Lin et al. (1995).
[Lin R] zu189 is Tc1 insertion allele, Tc1 mapped to BF8 +
Sequence connection from [Lin R, Thompson S, Priess JR], [krb 020702]
old_name sys-2 becomes new_name pop-1 from [Kimble JE].
MethodGene