RNAiDB Tree View

Gene: WBGene00000378

WBGene00000378	Identity (5)
	Gene_info	Gene_class	cct
		Phenotype	[C.elegansII] NMK. Encodes one of 7-9 related subunits of eukaryotic cytosolic chaperonin CCT. Ortholog of mouse Cctb (66% aa sequence identity)[PC]
		Structured_description	Provisional_description	cct-2 encodes a component of the eukaryotic cytosolic ('T complex') chaperonin; CCT-2 is expressed in touch receptors in a mec-3-dependent fashion, and may enable microtubule assembly.	Paper_evidence	WBPaper00002338
						WBPaper00005356
						WBPaper00013592
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				CCT-2 is orthologous to the mouse chaperonin Cctb, and homologous to the archaebacterial chaperonin TF55; along with cct-1 and cct-4, cct-2 mRNA is enriched in cultured touch receptor neurons, with respect to bulk RNA, to roughly the same degree that mec-3 mRNA is.
				Direct examination of cct-2 and cct-4 expression patterns, in fact, shows that they are expressed in touch receptors and that this expression depends on mec-3; since cct-2 (and cct-4) also show expression in other tissues, the gene is presumably subject to at least two independent means of regulation.
				The processes of touch receptors are packed with unusual, 15-protofilament microtubules20 that are formed from beta-tubulin and alpha-tubulin encoded by mec-7 and mec-12; since T complex chaperonin has been implicated in the correct folding of alpha- and beta-tubulin and in microtubule assembly, expression of CCT-2 (with CCT-1 and CCT-4) in these receptors is reasonable.
			Concise_description	cct-2 encodes a component of the eukaryotic cytosolic ('T complex') chaperonin; CCT-2 is expressed in touch receptors in a mec-3-dependent fashion, and may enable microtubule assembly.
	Reference (5)
	Method	Gene