WBGene00001097 | Evidence | Paper_evidence | WBPaper00005018
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| Chromosome | V |
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Identity (5)
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Gene_info
| Gene_class | dsc
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| | Allele | qm142
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Structured_description
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Provisional_description
| dsc-2 negatively regulates CLK-1-dependent defecation rhythm, but has no role in CLK-1-dependent adjustment of defecation to temperature; the dsc-2(qm142) mutation may produce a dominant-negative, antimorphic DSC-2 protein; dsc-2 is uncloned. |
Paper_evidence
| WBPaper00005018
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| | | | | | WBPaper00010277
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | Whereas clk-1 mutations cause slow defecation at 20 degrees C, dsc-2 mutations suppress this phenotype, but do not suppress the defect of clk-1 animals in adjusting their defecation cycle length in response to changes in temperature. |
| | | | The dsc-2(qm142) mutation has a semidominant, time-dependent effect; heterozygotes [clk-1(qm30; dsc-2(qm142)/+] begin adult life slower than normal, but 8 hours after the adult molt are normal, and 18 hours after molting have faster defecation than normal; dsc-2(qm142) may thus encode an antimorphic DSC-2 protein. |
| | | | dsc-2 cannot suppress the slow development of clk-1 mutants or other slow clk-1 behaviors. |
| | | Concise_description | dsc-2 negatively regulates CLK-1-dependent defecation rhythm, but has no role in CLK-1-dependent adjustment of defecation to temperature; the dsc-2(qm142) mutation may produce a dominant-negative, antimorphic DSC-2 protein; dsc-2 is uncloned. |
| Reference | WBPaper00005018
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| Method | Gene
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