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Gene: WBGene00001097   

WBGene00001097EvidencePaper_evidenceWBPaper00005018
ChromosomeV
Identity (5)
Gene_info Gene_classdsc
Alleleqm142
Structured_description Provisional_description dsc-2 negatively regulates CLK-1-dependent defecation rhythm, but has no role in CLK-1-dependent adjustment of defecation to temperature; the dsc-2(qm142) mutation may produce a dominant-negative, antimorphic DSC-2 protein; dsc-2 is uncloned. Paper_evidence WBPaper00005018
WBPaper00010277
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Whereas clk-1 mutations cause slow defecation at 20 degrees C, dsc-2 mutations suppress this phenotype, but do not suppress the defect of clk-1 animals in adjusting their defecation cycle length in response to changes in temperature.
The dsc-2(qm142) mutation has a semidominant, time-dependent effect; heterozygotes [clk-1(qm30; dsc-2(qm142)/+] begin adult life slower than normal, but 8 hours after the adult molt are normal, and 18 hours after molting have faster defecation than normal; dsc-2(qm142) may thus encode an antimorphic DSC-2 protein.
dsc-2 cannot suppress the slow development of clk-1 mutants or other slow clk-1 behaviors.
Concise_descriptiondsc-2 negatively regulates CLK-1-dependent defecation rhythm, but has no role in CLK-1-dependent adjustment of defecation to temperature; the dsc-2(qm142) mutation may produce a dominant-negative, antimorphic DSC-2 protein; dsc-2 is uncloned.
ReferenceWBPaper00005018
MethodGene