RNAiDB Tree View

Gene: Y104H12A.1

Y104H12A.1	SMap	S_parent	Sequence	SUPERLINK_RW4
	Chromosome	IV
	Identity (5)
	Gene_info	Gene_class	nhr
		Allele	ok584	Inferred_automatically	From strain object: RB794
			cxP5010
			snp_Y77E11[1]
		Strain	RB794
		Structured_description	Provisional_description	nhr-41 encodes a nuclear receptor of the NR2D1 subfamily that is orthologous to the Drosophila DHR78 nuclear receptor essential for the onset of metamorphosis, and the mammalian TR2 and TR4 receptors which are expressed in androgen-sensitive organs and brain tissue, respectively; by homology, NHR-41 likely functions as a transcription factor that, based upon RNAi experiments, plays a role in the formation of SDS-resistant dauer larvae; using two different reporter fusions, nhr-41 expression is detected in seam cells, excretory cells, and rectal epithelia, or in chemosensory neurons, gut, and head and tail hypodermis; nhr-41 mRNAs are expressed at all larval stages at precise intervals relative to molting: mRNA produced by upstream promoter sequence is detected at the time larval molts occur, while mRNA produced by promoter sequence in the fourth intron is detected at variable levels during larval development with distinct peaks of expression seen at the beginning of the intermolt.	Paper_evidence	WBPaper00006412
					Curator_confirmed	WBPerson1843
					Date_last_updated	07 Feb 2005 00:00:00
			Concise_description	nhr-41 encodes a nuclear receptor of the NR2D1 subfamily that is orthologous to the Drosophila DHR78 nuclear receptor essential for the onset of metamorphosis, and the mammalian TR2 and TR4 receptors which are expressed in androgen-sensitive organs and brain tissue, respectively; by homology, NHR-41 likely functions as a transcription factor that, based upon RNAi experiments, plays a role in the formation of SDS-resistant dauer larvae; using two different reporter fusions, nhr-41 expression is detected in seam cells, excretory cells, and rectal epithelia, or in chemosensory neurons, gut, and head and tail hypodermis; nhr-41 mRNAs are expressed at all larval stages at precise intervals relative to molting: mRNA produced by upstream promoter sequence is detected at the time larval molts occur, while mRNA produced by promoter sequence in the fourth intron is detected at variable levels during larval development with distinct peaks of expression seen at the beginning of the intermolt.
	Molecular_info (5)
	Experimental_info	RNAi_result	Cenix:134-d9
			Cenix:191-b8
			JA:Y104H12A.1
			JA:Y77E11A_3443.a
		WB_RNAi_result (5)
		Expr_pattern	Expr2869
			Expr2870
			Expr2871
		Y2H_target (11)
	Reference	WBPaper00006412
		WBPaper00010604
		WBPaper00018194
		WBPaper00023159
		WBPaper00026627
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene