RNAiDB Tree View

Gene: Y105C5B.21

Y105C5B.21	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	Y105C5B
	Chromosome	IV
	Identity (5)
	Gene_info	Gene_class	jac
		Allele (11)
		GO_term	GO:0005488	IEA	Inferred_automatically
		Structured_description	Provisional_description	jac-1 encodes the C. elegans p120 catenin orthologue; by homology, JAC-1 is predicted to be a component of the cadherin-catenin complex (CCC); although loss of jac-1 activity via RNAi does not result in obvious defects, jac-1(RNAi) does enhance embryonic morphogenesis defects produced by weak loss-of-function mutations in hmp-1/alpha-catenin, suggesting that JAC-1 positively regulates cadherin-catenin function in the embryo; JAC-1 likely regulates this function by promoting association between the actin cytoskeleton and the cadherin-catenin complex; a JAC-1 reporter fusion localizes to embryonic adherens junctions in a manner that is dependent upon the presence of HMR-1/cadherin, with which it specifically interacts in the yeast two-hybrid system.	Paper_evidence	WBPaper00005972
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	10 Jan 2005 00:00:00
			Concise_description	jac-1 encodes the C. elegans p120 catenin orthologue; by homology, JAC-1 is predicted to be a component of the cadherin-catenin complex (CCC); although loss of jac-1 activity via RNAi does not result in obvious defects, jac-1(RNAi) does enhance embryonic morphogenesis defects produced by weak loss-of-function mutations in hmp-1/alpha-catenin, suggesting that JAC-1 positively regulates cadherin-catenin function in the embryo; JAC-1 likely regulates this function by promoting association between the actin cytoskeleton and the cadherin-catenin complex; a JAC-1 reporter fusion localizes to embryonic adherens junctions in a manner that is dependent upon the presence of HMR-1/cadherin, with which it specifically interacts in the yeast two-hybrid system.
	Molecular_info (5)
	Experimental_info	RNAi_result	Cenix:141-e11
		WB_RNAi_result	MV_SV:mv_Y105C5B.21
			Cenix:141-e11
		Expr_pattern (3)
		Interaction	WBInteraction0002159
			WBInteraction0002954
	Reference	WBPaper00005972
		WBPaper00018753
		WBPaper00004885
		WBPaper00026603
	Remark	Sequence connection from [Pettitt J]
		Explanation and justification: This gene encodes the only C. elegans member of the p120 catenin family. p120 catenins bind to the juxtamembrane domain (JMD) of the classic cadherin cytoplasmic tail. The tail of HMR-1 possesses a well conserved JMD, suggesting that like other classic cadherins it binds p120 catenin. Consistent with this, localisation of GFP tagged JAC-1 to cell junctions is dependent upon HMR-1 function. In addition, jac-1(RNAi) enhances the mutant phenotype of a semi-viable allele of the alpha-catenin gene, hmp-1.
	Method	Gene