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Gene: Y116A8C.32   

Y116A8C.32SMapS_parentSequenceY116A8C
ChromosomeIV
Identity (5)
Gene_info GO_termGO:0003676 IEA Inferred_automatically
Contained_in_operonCEOP4596
Structured_description Provisional_descriptionY116A8C.32 encodes an ortholog of splicing factor SF1, which enables 3' splice site recognition by binding U2AF65 and the intron branch site during splicing complex formation; Y116A8C.32 shares several domains with mammalian SF1 proteins (a U2AF65 binding domain, a hnRNP K homology domain, two RNA-binding zinc knuckles, and a proline-rich C-terminal domain), while also sharing a hydrophilic N-terminal domain (enriched for serine, arginine, lysine, and aspartate) with Drosophila but not mammalian SF1; Y116A8C.32's N-terminal domain resembles RS domains in other splicing proteins; Y116A8C.32 is required for embryonic viability, normally rapid growth, and proper body morphology. Paper_evidence WBPaper00003817
WBPaper00005654
Person_evidenceWBPerson71
Curator_confirmedWBPerson71
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionY116A8C.32 encodes an ortholog of splicing factor SF1, which enables 3' splice site recognition by binding U2AF65 and the intron branch site during splicing complex formation; Y116A8C.32 shares several domains with mammalian SF1 proteins (a U2AF65 binding domain, a hnRNP K homology domain, two RNA-binding zinc knuckles, and a proline-rich C-terminal domain), while also sharing a hydrophilic N-terminal domain (enriched for serine, arginine, lysine, and aspartate) with Drosophila but not mammalian SF1; Y116A8C.32's N-terminal domain resembles RS domains in other splicing proteins; Y116A8C.32 is required for embryonic viability, normally rapid growth, and proper body morphology.
Molecular_info (6)
Experimental_info RNAi_result JA:Y116A8C.32
Simmer:Y116A8C.32
Cenix:46-e4
WB_RNAi_result JA:Y116A8C.32
Simmer:Y116A8C.32
Cenix:46-e4
ReferenceWBPaper00003817
MethodGene