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Structured_description
| Provisional_description | cnt-1 encodes a homolog of centaurin beta, an Arf GTPase activating protein (Arf GAP) that also contains a pleckstrin homology domain and C-terminal ankyrin repeats; by homology, CNT-1 is predicted to function as an Arf GAP that stimulates Arf GTPase activity and links cell signaling with cytoskeletal rearrangements and membrane trafficking; however, as loss of cnt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cnt-1 in C. elegans development and/or behavior is not yet known; cnt-1 is broadly expressed, being detected in the pharynx, excretory cell, spermatheca, distal tip cells of the gonad, neurons of the head and nerve ring, and anal epithelial cells; CNT-1 is able to bind the phosphoinositides PIP2 and PIP3 and upon production of PIP3, can translocate from the cytoplasm to the membrane. |
Paper_evidence (5)
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| | | Concise_description | cnt-1 encodes a homolog of centaurin beta, an Arf GTPase activating protein (Arf GAP) that also contains a pleckstrin homology domain and C-terminal ankyrin repeats; by homology, CNT-1 is predicted to function as an Arf GAP that stimulates Arf GTPase activity and links cell signaling with cytoskeletal rearrangements and membrane trafficking; however, as loss of cnt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cnt-1 in C. elegans development and/or behavior is not yet known; cnt-1 is broadly expressed, being detected in the pharynx, excretory cell, spermatheca, distal tip cells of the gonad, neurons of the head and nerve ring, and anal epithelial cells; CNT-1 is able to bind the phosphoinositides PIP2 and PIP3 and upon production of PIP3, can translocate from the cytoplasm to the membrane. |