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Gene: Y22D7AL.5   

Y22D7AL.5EvidencePaper_evidenceWBPaper00005851
SMapS_parentSequenceY22D7AL
ChromosomeIII
Identity (5)
Gene_info Gene_classhsp
Allele (5)
GO_term GO:0005515 IEA Inferred_automatically
GO:0005524 IEA Inferred_automatically
GO:0044267 IEA Inferred_automatically
Structured_description Provisional_description hsp-60 encodes a mitochondrial-specific chaperone that is a member of the GroE/Hsp10/60 superfamily of molecular chaperones; hsp-60 is believed to be involved in the mitochondrial unfolded protein response, as hsp-60 expression, normally broadly detected during development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-60 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development.Paper_evidenceWBPaper00024269
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated07 Jan 2005 00:00:00
hsp-60 is nuclear-encoded.
Concise_descriptionhsp-60 encodes a mitochondrial-specific chaperone that is a member of the GroE/Hsp10/60 superfamily of molecular chaperones; hsp-60 is believed to be involved in the mitochondrial unfolded protein response, as hsp-60 expression, normally broadly detected during development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-60 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development.
Molecular_info (5)
Experimental_info RNAi_resultCenix:177-b5
WB_RNAi_result MV_SV:mv_AAA28077
Cenix:177-b5
Gene_regulationTrans_targetcgc6848_hsp-60
Reference WBPaper00024269
WBPaper00024340
WBPaper00026640
MethodGene