Y37H2C.3 | SMap | S_parent | Sequence | SUPERLINK_CB_V
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| Chromosome | V |
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Identity
| Version | 1 |
| |
Name
| Sequence_name | Y37H2C.3
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| | |
Molecular_name
| Y37H2C.3
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| | | | WP:CE19091
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| | | | CE19091
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| | | Public_name | Y37H2C.3
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| | |
Synonym
| Y37H2C.3
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| | | | WP:CE19091
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| | | | CE19091
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| | | WBGeneID | WBGene00012574
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| | Species | Caenorhabditis elegans
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| | History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971
| Event | Imported | Initial conversion from CDS class of WS125 |
| | Status | Live |
| Gene_info |
Structured_description
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Provisional_description
| This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. | Paper_evidence | WBPaper00012854
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | The F-box motif consists of roughly 50 amino acids. |
| | | | There are at least 11 F-box genes encoded by the genome of budding yeast, 22 in Drosophila, and 38 in human beings; but a striking 326 F-box genes are predicted to exist in C. elegans, comprising 1.6% of the protein-coding genome. |
| | | | This disproportionate number of F-box genes is paralleled by the number of Skp-1 homologs (which are potential F-box ligands) encoded in these genomes: while there are 2, 7, and 1 Skp-1 related genes predicted in the genomes of Dictyostelium discoideum, Drosophila, and Homo sapiens, there are 17 Skp-1 homologs in C. elegans. |
| | | | F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, Skp-1, Cullin, and an F-box protein), in which they bind substrates for ubiquitination (and, thus, subsequent proteolysis); in SCF complexes, the F-box motif links its protein to other SCF components by binding Skp-1 protein. |
| | | | However, F-box proteins are by no means confined solely to SCF complexes: for instance, yeast Skp-1 can bind non-SCF F-box proteins to perform cellular functions completely distinct from protein degradation, such as kinetochore function (binding the F-box protein Ctf13p) or SNARE recycling (by binding the F-box protein Rcy1p), as well as yet other F-box proteins of unknown function (Yjl149 and Yml088). |
| | | Concise_description | This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. |
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Molecular_info
| Corresponding_CDS | Y37H2C.3
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| | Corresponding_protein | WP:CE19091
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| | Corresponding_PCR_product | sjj_Y37H2C.3
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Corresponding_RNAi_reagent
| Cenix:50-d8
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| | | sjj_Y37H2C.3
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| | | mv_Y37H2C.3
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Experimental_info
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RNAi_result
| Cenix:50-d8
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| | | JA:Y37H2C.3
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WB_RNAi_result
| JA:Y37H2C.3
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| | | MV_SV:mv_Y37H2C.3
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| | | Cenix:50-d8
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| Method | Gene
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